Physiological transporters (aka “drug transporters”) are seemingly a one-way gate for substances to pass from one carrier to another. Using an airport as an analogy, a range of carriers – cars, buses, trains, ferries, trams, other – carry a person from somewhere to the departure lounge of the airport, the person passes through one or

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A recent seminal study (DOI 10.1074/jbc.RA120.013610) found that ThTr1/2 (Thiamine Transporters 1/2) can transport both thiamine and pyridoxine from the brush border membranes of the small intestines into the epithelial cells. This study established 3 key findings, being -the first to identify an intestine-to-epithelium transporter for pyridoxine,that ThTr 1/2 are actually multi-specific transporters that can

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Personalising templates is a more effective use of time than writing each essentially-similar entry from scratch – the days we are tired or rushed or distracted are the days we leave out something important. Another benefit that templates confer is the consistency of the information being passed on which means the readers are more likely to

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Whilst researching a related topic for a soon-to-be-published MedNut Mail email, I came across this diagram and asked the question “what are the likely mechanisms of action for metformin to alter pyridoxine’s (vitamin B6) metabolic pathway?”There is now early evidence that metformin use is associated with a higher risk of B6 deficiency, with one study

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A fall is defined as an event in which a person inadvertently comes to rest on the ground or other lower level. A fall can result in physical harm such as broken skin and bones, emotional and mental harm such as loss of confidence, and damaged ego as falling is quite inelegant. Falls are the

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Nutrition support products are typically administered if a person has lost weight or has very poor appetite, and their purpose is to improve nutritional health, with success typically being identified as weight gain. They are formulaic drinks based on either water or milk and typically contain a range of added nutrients.The article titled Distribution of

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Templates are useful to ensure inclusion of relevant points and to streamline work efficiency. Further, they can be amended as new research adds to our body of knowledge. These templates have focussed on some of the negative pharmaconutritional impacts of diabetes – a diagnosis that seems to be the forerunner of further poor health.Diabetes drugsXXXXX

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Enter your text here..Constipation is a common side effect of many prescribed medications and contributes to further issues such as increased brittleness in pain management, increased risk of falling, increased confusion, increased frequency and duration of parkinson’s freezing, increased frequency and duration of difficult, resistive, aggressive behaviours, inexplicable vomiting, etc. These consequences typically result in

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Biotin is a B vitamin that helps the body break down fats, carbohydrates, and proteins and is important in cell growth, the metabolism of fats and amino acids, and energy production; roles include –cofactor for a small group of enzymes catalyzing carboxylation, decarboxylation, and transcarboxylation reactions in fatty acid, glucose and amino acid metabolism and

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Templates are useful for ensuring essential information is passed on without any aspect being overlooked as they can be copied, pasted and modified as required. These templates have focussed on some of the negative nutritional impacts of proton pump inhibitors (PPI) primarily because they seem to be about as popular to consume as lollies!Currently prescribed

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MELAS (Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like) is caused by mutations in mitochondrial DNA and is considered to be an Inborn Error of Metabolism. Clinical manifestation is typically before the age of 40 therefore presentation in older adults is very unusual.I found this man (details in Case Study) several years ago and there was very

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… hSVCT1 (Sodium Vitamin C Transporter 1) expression and function were significantly decreased in intestinal epithelial cells by the histone deacetylase inhibitors (in Australia – Vorinostat – Zolinza), valproic acid, and sodium butyrate (NaB) is part of a comment from a recent abstract (https://doi.org/10.1016/j.jnutbio.2021.108838). Effectively this means sodium valproate decreases vitamin C absorption. As we are

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This email is based on a question from a reader. I have a client who is tube fed, currently on XXX enteral feed as she can’t tolerate regular/standard formula.  She is on a few medications that affect carnitine levels/absorption- including Frisium, Epillim and Lamictal. She has been experiencing a lot of the symptoms also associated with carnitine deficiency,

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Deafness is a multifactorial, global health issue that is commonly inadequately managed in healthcare services; for example a person who responds inappropriately to a question is automatically labelled “? dementia” and no-one even considers the alternative ie “? deafness”.When a deaf person does not respond appropriately, even when spoken to with a raised voice, then

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From a practical, work efficiency perspective, many of the people we see are prescribed similar combinations of medications and so we find we’re frequently repeating ourselves. For my clinical practice I created a file called Regular Notes, in which I templated much of the repeatable content with identifiers for the bits requiring change (people names,

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Calcium carbonate is a commonly prescribed therapeutic intervention and is listed on the Pharmaceutical Benefits Scheme (PBS). However, there is increasing concern regarding the therapeutic effectiveness of calcium carbonate when there is concurrent administration of a proton pump inhibitor (PPI).Calcium is primarily absorbed throughout the intestines and predominantly from the duodenum and jejunum.Calcium carbonate.Calcium carbonate

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Money and nutrients have some surprising commonalities –similar income/intake on a relatively regular basis,other income/intake on a regular basis,regular costs,pleasure costs.Money management typically starts with a budget – with a defined portion of money being allocated to various accounts such as regular bills, mortgage/loan repayments, Xmas/holidays, savings, and what’s left, and possibly a bit more,

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Commonly the pre-breakfast BSLs may be the only routine monitoring strategy for those with long term diabetes and deemed relatively stable. Further, commonly, if the pre-breakfast BSL is within acceptable range then further daily monitoring is rarely considered. Therefore, those people with diabetes and who are also prescribed prednisolone may be experiencing regular afternoon hyperglycaemia

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Some people can be prescribed medications from a very young age eg diabetes, epilepsy, and will consume a range of medications for most of their lives ie for decades. As the limited research indicates there are potentially many significant negative impacts that some of these longterm drugs may have on nutrient status and consequently health

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