An aspirin-folic acid interaction was a recent “incidental finding” from a pooled analysis of some studies looking at brain atrophy ...

Osmolality seems to be a rarely-considered contributor to a range of primarily gastro-intestinal side effects – and is probably overlooked ...

“Not to be crushed, chewed, broken or dissolved” and its many variations are commonly included in most medicines Product Information ...

Excipients are the ingredients that comprise about 90% of a medicine - they are added to optimise some aspect of ...

“Not clinically relevant”, “inhibition unlikely at therapeutic interventions”, “clinical inhibition deemed minimal”, and similar other phrases typically refer to drug-transporter ...

The side effects of many prescribed medicines include altered glycaemic status which is associated with physical harm to the body. ...

Multidrug resistance proteins (MRPs) are efflux transporters and as such are responsible for the movement of a wide variety of ...

Role/functionOATs are primarily influx transporters albeit some are bidirectional, that with their multi-specific binding pockets are able to transport a ...

Organic Anion Transporting Proteins (OATPs) are influx transporters ie transport substrates from blood into organs and cells. OATPs can transport ...

Permeability-glycoprotein is known as P-glycoprotein or P-gp or multidrug resistance protein (MDR1/2); it has a large and versatile drug-binding region ...

The Sodium Vitamin C Transporters (SVCTs) regulate vitamin C homeostasis (system stability) such that excessive intakes result in reduced intestinal ...

Multi drug and toxin exclusion transporters (MATE1) and (MATE2) are major efflux transporters involved in the hepatic and renal excretion ...

Breast Cancer Resistance Protein (BCRP) seems to be an initial defence against environmental insults such as phototoxic skin lesions, and ...

The thiamine transporters Thiamine Transporter 1 (THTR1) and Thiamine Transporter 2 (THTR2) transfer thiamine and pyridoxine, and are associated with ...

Sodium Multivitamin Transporter (SMVT) facilitates the uptake of biotin, pantothenic acid, lipoic acid, and iodine from the gut and across ...

The organic cation transporters regulate the transfer of many essential organic cations across biological membranes and therefore have an essential ...

Membrane transporters enable substances to cross impermeable cell membranes. Whilst they primarily transfer endogenous substances such as nutrients, they can ...

Metformin’s role in healthcare management is expanding and is now being considered as a treatment for some cancers, bone health, ...

Coagulation (blood clotting) is a process that prevents excessive bleeding when a blood vessel is injured. Usually, a blood clot ...

DOACs (direct oral anticoagulants) are becoming the preferred option for coagulation management because they do not require the management strategies ...