Comprehensive and reliable information on drug-nutrient interactions

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This resource lists a comprehensive range of drugs (~ 6,000) that are associated with the drug:nutrition interface i.e. drug effects on nutritional factors (drug-nutrient interactions, drug-food interactions) and the effects of nutritional factors on drug effects (eg malnutrition, weight change).

Included as available is the evidence relating to many of the following issues:

  • Altered drug absorption dynamics. Examples include concurrent administration of calcium supplements with levodopa reduces availability of levodopa dose.
  • Altered nutrient absorption dynamics. For example acid-inhibiting medicines alter gastric acidity and decrease absorption of vitamin C.
  • Altered nutrient excretion dynamics. For example digoxin increases magnesium excretion via the kidneys.
  • Impacts of side effects. For example some statins negatively impact appetite with ongoing loss of weight as the outcome.
  • Impacts of specific nutrient supplements. For example iron supplements alter gut microbiota in favour of pathogens.
  • Potential excipient harm. Excipients (the ingredients mixed with the active ingredient) may cause harm for those with specific food allergies and intolerances such as gluten, lactose, galactose, phenylalanine, etc.
  • Manufacturers’ administration recommendations. This is particularly relevant to those with impaired swallow reflex or for those requiring enteral feeding. Alteration in medicine form or delivery format potentially alters its rate of absorption and extent of effect.
  • Thiamine transporters and prescribed medicines. Which drugs can be transported by and/or inhibit the function of thiamine transporters? “Drug transporters” are in reality, physiological transporters that can also conveniently transport certain drugs; this area of drug transport is currently undergoing significant research.

Medications & Nutrition

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