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  • Category: PharmacoNutrition

The interface between prescribed medicines and nutritional factors is so overlooked that it is commonly referred to as drug-nutrient interactions. We decided PharmacoNutrition is a suitable name as it encompasses the broad scope of the field. Pharmaconutrition interactions are overlooked because -

  • research papers are scattered across a plethora of journals and subjects;
  • the studies are mostly small;
  • there is an assumption, without evidence, that food intake will cover the drug-induced nutrient losses;
  • there is also an assumption by the pharmaceutical sector that food is benign – this assumption is steadily being eroded,
  • the training for doctors and pharmacists training does not include a significant nutrition component. This is surprising given 80+% of western ill-health has an underlying negative nutrition component.
The ultimate question is “Who will conduct the research?”:
  • pharmaceutical industry. The regulatory processes do not require negative nutritional impacts of pharmaceutical products to be included in the drug discovery process;
  • governmental research bodies. The number of similarly worthwhile research projects competing for funding is steadily increasing whilst the funding sources generally are not;
  • philanthropic bodies. Philanthropic bodies either support a specific area of research or dispense smaller grants to a larger number of applicants. Sadly, there aren't any philanthropic bodies with a particular interest in this area of expertise.
PharmacoNutrition comprises 2 components -
  • accessing the information, and
  • presenting the findings in a clinically meaningful format.
The online platform Medications & Nutrition provides a comprehensive range of clinically-useful, referenced, research evidence that is presented in a dot point format to improve accessibility to the latest research for busy clinicians. Examples of integration formats are included in the Case study component of our MedNut Mail series.

September 11, 2023

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Altered glycaemia and Vitamin C

Mechanisms and consequencesThe side effects of many prescribed medicines include altered glycaemic status which is associated with physical harm to ...

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August 1, 2023

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Multidrug Resistance Proteins (MRPs) and pharmaconutrition

Mechanisms and consequencesMultidrug resistance proteins (MRPs) are efflux transporters and as such are responsible for the movement of a wide ...

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July 24, 2023

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Guest case study – hypercalcaemia

Guest case studyGuest case study - hypercalcaemia is based on a question from a concerned clinician.Oral calcium intake - no ...

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July 10, 2023

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Organic Anion Transporters (OATs) and pharmaconutrition

Mechanisms and consequencesOATs(Organic Anion Transporters) are primarily influx transporters albeit some are bidirectional. They can transport a wide variety of ...

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June 26, 2023

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Organic Anion Transporting Polypeptides (OATPs) and pharmaconutrition

Mechanisms and consequencesOATPs (Organic Anion Transporting Proteins) are influx transporters ie transport substrates from blood into organs and cells. OATPs ...

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June 12, 2023

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P-glycoprotein and pharmaconutrition

Mechanisms and consequencesPermeability-glycoprotein is known as P-glycoprotein or P-gp or multidrug resistance protein (MDR1/2); it has a large and versatile ...

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May 29, 2023

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Sodium Vitamin C Transporters and pharmaconutrition

Mechanisms and consequencesThe Sodium Vitamin C Transporters (SVCTs) regulate vitamin C homeostasis (system stability) such that excessive intakes result in ...

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May 22, 2023

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MATE1/2 and pharmaconutrition

Mechanisms and consequencesMATE1/2 (Multi drug and toxin exclusion transporters MATE1 and MATE2) are major efflux transporters involved in the hepatic ...

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May 15, 2023

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BCRP and pharmaconutrition

Mechanisms and consequencesBCRP (Breast Cancer Resistance Protein) seems to be an initial defence against environmental insults such as phototoxic skin ...

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May 8, 2023

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Thiamine Transporters 1/2 and pharmaconutrition

Mechanisms and consequencesThe thiamine transporters Thiamine Transporter 1 (THTR1) and Thiamine Transporter 2 (THTR2) transfer thiamine and pyridoxine, and are ...

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May 1, 2023

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Sodium Multivitamin Transporter and pharmaconutrition

Mechanisms and consequencesSMVT (Sodium Multivitamin Transporter) facilitates the uptake of biotin, pantothenic acid, lipoic acid, and iodine from the gut ...

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April 10, 2023

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Organic Cation Transporters (OCTs) and pharmaconutrition

Mechanisms and consequencesOCTs regulate the transfer of many essential organic cations across biological membranes and therefore have an essential role ...

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April 3, 2023

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Membrane transporters and pharmaconutrition

Mechanisms and consequencesMembrane transporters enable substances to cross impermeable cell membranes. Whilst they primarily transfer endogenous substances such as nutrients, ...

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March 27, 2023

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Metformin and pharmaconutrition

Mechanisms and consequencesMetformin’s role in healthcare management is expanding and is now being considered as a treatment for some cancers, ...

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December 15, 2022

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Coagulation and pharmaconutrition

Mechanisms and consequencesCoagulation (blood clotting) is a process that prevents excessive bleeding when a blood vessel is injured. Usually, a ...

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December 5, 2022

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DOACs and pharmaconutrition

Mechanisms and consequencesDOACs (direct oral anticoagulants) are becoming the preferred option for coagulation management because they do not require the ...

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November 7, 2022

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Drug interactions and pharmaconutrition

Mechanisms and consequencesMedications, medicines, drugs are used interchangeably to describe chemical substances that are administered to confer therapeutic benefit; they ...

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November 2, 2022

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Acid-base balance and pharmaconutrition

Mechanisms and consequencesAcid-base imbalance is now being associated with a range of Western health disorders including insulin resistance, diabetes, thyroid ...

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October 24, 2022

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Steady state and pharmaconutrition

Mechanisms and consequencesSteady state concentration is the period during which the therapeutic levels remain constant. It is achieved when a ...

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October 17, 2022

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Non-insulin diabetes preparations and pharmaconutrition

Mechanisms and consequencesI now understand why duration of therapeutic effect of the non-insulin diabetes drugs is not an integral part ...

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