Drug-induced tipping points and health management strategies are an unlikely combination and rarely considered. A common definition (https://global-tipping-points.org/what-is-a-tipping-point/) for a ...
April 23, 2024
April 23, 2024
Drug-induced tipping points and health management strategies are an unlikely combination and rarely considered. A common definition (https://global-tipping-points.org/what-is-a-tipping-point/) for a ...
April 9, 2024
Levodopa + carbidopa and thiamine encompass a range of interactions that have significant consequences to Parkinson’s Disease (PD) progression. The ...
March 18, 2024
Levodopa + carbidopa and vitamin C encompass a range of interactions that include both direct and indirect mechanisms of action. ...
March 4, 2024
The levodopa + carbidopa and vitamin D interaction is apparently additive however the evidence is limited. Given Parkinson’s Disease is ...
February 19, 2024
Levodopa + carbidopa and zinc interactions are a surprisingly relatively recent finding. Levodopa is both a pharmaceutical and an amino ...
February 5, 2024
Is there evidence of a levodopa +carbidopa and manganese interaction? The total metal content and cellular compartmentalization of several key ...
January 29, 2024
The levodopa + carbidopa, magnesium and vitamin C interaction has only recently gained recognition. Levodopa is commonly prescribed for those ...
December 19, 2023
Interactions between aspirin and various nutrients have been identified over a number of decades and are either old, forgotten, or ...
December 13, 2023
An aspirin-folic acid interaction was a recent “incidental finding” from a pooled analysis of some studies looking at brain atrophy ...
December 4, 2023
The aspirin-vitamin C interaction was discovered in the early 1970’s. Much of the evidence is based on short term, high-dose ...
November 27, 2023
Osmolality seems to be a rarely-considered contributor to a range of primarily gastro-intestinal side effects – and is probably overlooked ...
October 16, 2023
“Not to be crushed, chewed, broken or dissolved” and its many variations are commonly included in most medicines Product Information ...
October 3, 2023
Excipients are the ingredients that comprise about 90% of a medicine - they are added to optimise some aspect of ...
September 18, 2023
“Not clinically relevant”, “inhibition unlikely at therapeutic interventions”, “clinical inhibition deemed minimal”, and similar other phrases typically refer to drug-transporter ...
September 11, 2023
The side effects of many prescribed medicines include altered glycaemic status which is associated with physical harm to the body. ...
August 1, 2023
Multidrug resistance proteins (MRPs) are efflux transporters and as such are responsible for the movement of a wide variety of ...
July 24, 2023
This email is based on a question from a concerned clinician.Oral calcium intake - no evidence of excessive calcium intake ...
July 10, 2023
Role/functionOATs are primarily influx transporters albeit some are bidirectional, that with their multi-specific binding pockets are able to transport a ...
June 26, 2023
Organic Anion Transporting Proteins (OATPs) are influx transporters ie transport substrates from blood into organs and cells. OATPs can transport ...
June 12, 2023
Permeability-glycoprotein is known as P-glycoprotein or P-gp or multidrug resistance protein (MDR1/2); it has a large and versatile drug-binding region ...